{"id":73881,"date":"2021-07-14T16:28:40","date_gmt":"2021-07-14T20:28:40","guid":{"rendered":"http:\/\/stateofthenation.co\/?p=73881"},"modified":"2021-07-14T16:29:32","modified_gmt":"2021-07-14T20:29:32","slug":"scientific-research-paper-ivermectin-proven-to-reduce-duration-of-covid-19","status":"publish","type":"post","link":"https:\/\/stateofthenation.co\/?p=73881","title":{"rendered":"SCIENTIFIC RESEARCH PAPER: Ivermectin Proven to Reduce Duration of COVID-19"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-73883\" src=\"http:\/\/stateofthenation.co\/wp-content\/uploads\/2021\/07\/Screen-Shot-2021-07-14-at-4.28.59-PM.png\" alt=\"\" width=\"762\" height=\"258\" srcset=\"https:\/\/stateofthenation.co\/wp-content\/uploads\/2021\/07\/Screen-Shot-2021-07-14-at-4.28.59-PM.png 762w, https:\/\/stateofthenation.co\/wp-content\/uploads\/2021\/07\/Screen-Shot-2021-07-14-at-4.28.59-PM-300x102.png 300w\" sizes=\"auto, (max-width: 762px) 100vw, 762px\" \/><\/p>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<h1 class=\"heading-title\">A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness<\/h1>\n<div class=\"inline-authors\">\n<div class=\"authors\">\n<div class=\"authors-list\"><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ahmed+S&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Sabeena Ahmed\">Sabeena Ahmed<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Karim+MM&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Mohammad Mahbubul Karim\">Mohammad Mahbubul Karim<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ross+AG&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Allen G Ross\">Allen G Ross<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hossain+MS&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Mohammad Sharif Hossain\">Mohammad Sharif Hossain<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Clemens+JD&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"John D Clemens\">John D Clemens<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sumiya+MK&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Mariya Kibtiya Sumiya\">Mariya Kibtiya Sumiya<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Phru+CS&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Ching Swe Phru\">Ching Swe Phru<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rahman+M&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Mustafizur Rahman\">Mustafizur Rahman<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zaman+K&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Khalequ Zaman\">Khalequ Zaman<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Somani+J&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Jyoti Somani\">Jyoti Somani<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Division of Infectious Diseases, Department of Medicine, National University Hospital, Singapore.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-2\">2<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Yasmin+R&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Rubina Yasmin\">Rubina Yasmin<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Mugda Medical College and Hospital, Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-3\">3<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hasnat+MA&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Mohammad Abul Hasnat\">Mohammad Abul Hasnat<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Kurmitola General Hospital, Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-4\">4<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kabir+A&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Ahmedul Kabir\">Ahmedul Kabir<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Dhaka Medical College and Hospital, Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-5\">5<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Aziz+AB&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Asma Binte Aziz\">Asma Binte Aziz<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Khan+WA&amp;cauthor_id=33278625\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Wasif Ali Khan\">Wasif Ali Khan<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. Electronic address: wakhan@icddrb.org.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/#affiliation-6\">6<\/a><\/sup><\/span><\/div>\n<\/div>\n<\/div>\n<div class=\"short-article-details\">Affiliations\u00a0<button id=\"toggle-authors\" class=\"more-details\" data-alt-text=\"Collapse\" aria-controls=\"expanded-authors\" aria-expanded=\"false\" data-pinger-ignore=\"\" data-fetch-url=\"\/33278625\/long-authors\/\" data-id-prefix=\"\"><span class=\"title\">expand<\/span><\/button><\/div>\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:\u00a0<\/span><strong class=\"current-id\" title=\"PubMed ID\">33278625<\/strong><\/span><\/li>\n<li><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:\u00a0<\/span><a class=\"id-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7709596\/\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"PMCID\">PMC7709596<\/a><\/span><\/li>\n<li><span class=\"identifier doi\"><span class=\"id-label\">DOI:\u00a0<\/span><a class=\"id-link\" href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.11.191\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1016\/j.ijid.2020.11.191<\/a><\/span><\/li>\n<\/ul>\n<p><span class=\"free-label\">Free PMC article<\/span><\/p>\n<\/div>\n<\/header>\n<p><!--more--><\/p>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. A randomized, double-blind, placebo-controlled trial was conducted to determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients. The trial included 72 hospitalized patients in Dhaka, Bangladesh, who were assigned to one of three groups: oral ivermectin alone (12 mg once daily for 5 days), oral ivermectin in combination with doxycycline (12 mg ivermectin single dose and 200 mg doxycycline on day 1, followed by 100 mg every 12 h for the next 4 days), and a placebo control group. Clinical symptoms of fever, cough, and sore throat were comparable among the three groups. Virological clearance was earlier in the 5-day ivermectin treatment arm when compared to the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27). There were no severe adverse drug events recorded in the study. A 5-day course of ivermectin was found to be safe and effective in treating adult patients with mild COVID-19. Larger trials will be needed to confirm these preliminary findings.<\/p>\n<\/div>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>Bangladesh; COVID-19; Doxycycline; Ivermectin; SARS-CoV-2.<\/p>\n<\/div>\n<p id=\"copyright\" class=\"copyright\">Copyright \u00a9 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.<\/p>\n<div id=\"conflict-of-interest\" class=\"conflict-of-interest\">\n<h3 class=\"title\">Conflict of interest statement<\/h3>\n<div class=\"statement\">\n<p>The authors declare that there are no known competing financial interests or personal relationships that could have appeared to influence the work described in this paper.<\/p>\n<\/div>\n<\/div>\n<div id=\"figures\" class=\"figures\">\n<h3 class=\"title\">Figures<\/h3>\n<div id=\"slides-container\" class=\"figures-list\">\n<figure class=\"figure-item \" data-slide-index=\"0\" data-label-slug=\"figure-1\"><a class=\"figure-link\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7709596\/bin\/gr1_lrg.jpg\" aria-describedby=\"figure-caption-0\" data-image-width=\"694\" data-image-height=\"342\" data-image-alt=\"Figure 1\" data-pmc-id=\"PMC7709596\" data-figure-id=\"fig0005\"><img decoding=\"async\" id=\"article-image-0\" class=\"figure-thumb\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7709596\/bin\/gr1_lrg.gif\" alt=\"Figure 1\" \/><\/a><\/p>\n<div class=\"figure-caption figure-caption-text\" aria-hidden=\"true\">\n<div class=\"caption-wrap\">\n<p>Figure 1<\/p>\n<div class=\"figure-caption-contents\">\n<p>Cumulative viral recovery estimates in\u2026<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/figure>\n<\/div>\n<\/div>\n<div id=\"similar\" class=\"similar-articles\">\n<h2 class=\"title\">Similar articles<\/h2>\n<ul id=\"similar-articles-list\" class=\"articles-list\">\n<li class=\"full-docsum\">\n<div class=\"docsum-content\">\n<p><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33234158\/\" data-ga-category=\"similar_article\" data-ga-action=\"33234158\" data-ga-label=\"\">Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19): a structured summary of a study protocol for a randomized controlled trial.<\/a><\/p>\n<div class=\"docsum-citation full-citation\"><span 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