{"id":74324,"date":"2021-07-17T17:43:39","date_gmt":"2021-07-17T21:43:39","guid":{"rendered":"http:\/\/stateofthenation.co\/?p=74324"},"modified":"2021-07-17T17:43:39","modified_gmt":"2021-07-17T21:43:39","slug":"check-out-this-postmortem-conducted-on-a-covid-vaccinated-patient","status":"publish","type":"post","link":"https:\/\/stateofthenation.co\/?p=74324","title":{"rendered":"Check out this postmortem conducted on a Covid-vaccinated patient."},"content":{"rendered":"

First case of postmortem study in a patient vaccinated against SARS-CoV-2<\/h1>\n

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Torsten<\/span>Hansen<\/span>a<\/sup><\/span><\/span><\/a><\/a><\/p>\n

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Ulf<\/span>Titze<\/span>a<\/sup><\/span><\/span><\/a>Nidhi Su Ann<\/span>Kulamadayil-Heidenreich<\/span>b<\/sup><\/span><\/span><\/a>Sabine<\/span>Glombitza<\/span>c<\/sup><\/span><\/span><\/a>Johannes Josef<\/span>Tebbe<\/span>b<\/sup><\/span><\/span><\/a>Christoph<\/span>R\u00f6cken<\/span>d<\/sup><\/span><\/span><\/a>Birte<\/span>Schulz<\/span>a<\/sup><\/span><\/span><\/a>Michael<\/span>Weise<\/span>b<\/sup><\/span><\/span><\/a>Ludwig<\/span>Wilkens<\/span>c<\/sup><\/span><\/span><\/a><\/p>\n

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a<\/sup><\/dt>\n
Institute of Pathology, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany<\/dd>\n<\/dl>\n
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b<\/sup><\/dt>\n
Department of Internal Medicine, Gastroenterology and Infectious Medicine, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany<\/dd>\n<\/dl>\n
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c<\/sup><\/dt>\n
Institute of Pathology, KRH Hospital Nordstadt, Hannover, Germany<\/dd>\n<\/dl>\n
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d<\/sup><\/dt>\n
Institute of Pathology of the University of Schleswig-Holstein, Campus Kiel, Germany<\/dd>\n<\/dl>\n<\/div>\n<\/div>\n

Received 25 February 2021, Revised 13 April 2021, Accepted 14 April 2021, Available online 16 April 2021.<\/p>\n

https:\/\/doi.org\/10.1016\/j.ijid.2021.04.053<\/a>Get rights and content<\/a><\/div>\n
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Under a Creative Commons license<\/a><\/div>\n
open access<\/div>\n<\/div>\n
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Highlights<\/h2>\n
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\u2022<\/dt>\n
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We report on a patient with a single dose<\/a> of vaccine against SARS-CoV-2.<\/p>\n<\/dd>\n

\u2022<\/dt>\n
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He developed relevant serum titer levels but died 4 weeks later.<\/p>\n<\/dd>\n

\u2022<\/dt>\n
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By postmortem molecular mapping, we found viral RNA<\/a> in nearly all organs examined.<\/p>\n<\/dd>\n

\u2022<\/dt>\n
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However, we did not observe any characteristic morphological<\/a> features of COVID-19.<\/p>\n<\/dd>\n

\u2022<\/dt>\n
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Immunogenicity<\/a> might be elicited, while sterile immunity was not established.<\/p>\n<\/dd>\n<\/dl>\n<\/div>\n<\/div>\n

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Abstract<\/h2>\n
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A previously symptomless 86-year-old man received the first dose of the BNT162b2 mRNA COVID-19 vaccine. He died 4 weeks later from acute renal and respiratory failure. Although he did not present with any COVID-19-specific symptoms, he tested positive for SARS-CoV-2 before he died. Spike protein (S1) antigen-binding showed significant levels for immunoglobulin (Ig) G, while nucleocapsid IgG\/IgM was not elicited. Acute bronchopneumonia and tubular failure were assigned as the cause of death at autopsy; however, we did not observe any characteristic morphological features of COVID-19. Postmortem molecular mapping by real-time polymerase chain reaction revealed relevant SARS-CoV-2 cycle threshold values in all organs examined (oropharynx, olfactory mucosa, trachea, lungs, heart, kidney and cerebrum) except for the liver and olfactory bulb. These results might suggest that the first vaccination induces immunogenicity but not sterile immunity.<\/p>\n<\/div>\n<\/div>\n<\/div>\n