{"id":77736,"date":"2021-08-05T18:33:44","date_gmt":"2021-08-05T22:33:44","guid":{"rendered":"http:\/\/stateofthenation.co\/?p=77736"},"modified":"2021-08-05T18:33:44","modified_gmt":"2021-08-05T22:33:44","slug":"here-read-this-postmortem-scientific-research-paper-on-a-covid-vaccinated-patient-before-its-retracted","status":"publish","type":"post","link":"https:\/\/stateofthenation.co\/?p=77736","title":{"rendered":"Here, read this postmortem Scientific Research Paper on a Covid-vaccinated patient before it’s retracted."},"content":{"rendered":"

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Int J Infect Dis.<\/a><\/span> 2021 Jun; 107: 172\u2013175.<\/div>\n
Published online 2021 Apr 16. <\/span> doi:\u00a010.1016\/j.ijid.2021.04.053<\/a><\/span><\/div>\n<\/div>\n<\/div>\n
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PMCID: <\/span>PMC8051011<\/div>\n
PMID: 33872783<\/a><\/div>\n<\/div>\n<\/div>\n

First case of postmortem study in a patient vaccinated against SARS-CoV-2<\/h1>\n
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Torsten Hansen<\/a>,a,<\/sup>\u204e<\/sup> Ulf Titze<\/a>,a<\/sup> Nidhi Su Ann Kulamadayil-Heidenreich<\/a>,b<\/sup> Sabine Glombitza<\/a>,c<\/sup> Johannes Josef Tebbe<\/a>,b<\/sup> Christoph R\u00f6cken<\/a>,d<\/sup> Birte Schulz<\/a>,a<\/sup> Michael Weise<\/a>,b<\/sup> and Ludwig Wilkens<\/a>c<\/sup><\/div>\n<\/div>\n
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Author information<\/a> Article notes<\/a> Copyright and License information<\/a> Disclaimer<\/a><\/div>\n<\/div>\n<\/div>\n
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Abstract<\/h2>\n
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A previously symptomless 86-year-old man received the first dose of the BNT162b2 mRNA COVID-19 vaccine. He died 4 weeks later from acute renal and respiratory failure. Although he did not present with any COVID-19-specific symptoms, he tested positive for SARS-CoV-2 before he died. Spike protein (S1) antigen-binding showed significant levels for immunoglobulin (Ig) G, while nucleocapsid IgG\/IgM was not elicited. Acute bronchopneumonia and tubular failure were assigned as the cause of death at autopsy; however, we did not observe any characteristic morphological features of COVID-19. Postmortem molecular mapping by real-time polymerase chain reaction revealed relevant SARS-CoV-2 cycle threshold values in all organs examined (oropharynx, olfactory mucosa, trachea, lungs, heart, kidney and cerebrum) except for the liver and olfactory bulb. These results might suggest that the first vaccination induces immunogenicity but not sterile immunity.<\/p>\n<\/div>\n

Keywords: <\/strong>SARS-CoV-2, Vaccine, Autopsy, Histology, RT-PCR<\/span><\/div>\n<\/div>\n
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We report on an 86-year-old male resident of a retirement home who received vaccine against SARS-CoV-2. Past medical history included systemic arterial hypertension, chronic venous insufficiency, dementia and prostate carcinoma. On January 9, 2021, the man received lipid nanoparticle-formulated, nucleoside-modified RNA vaccine BNT162b2 in a 30 \u03bcg dose. On that day and in the following 2 weeks, he presented with no clinical symptoms (Table 1<\/a> ). On day 18, he was admitted to hospital for worsening diarrhea. Since he did not present with any clinical signs of COVID-19, isolation in a specific setting did not occur. Laboratory testing revealed hypochromic anemia and increased creatinine serum levels. Antigen test and polymerase chain reaction (PCR) for SARS-CoV-2 were negative.<\/p>\n

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Table 1<\/h3>\n
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Summary of major features of the patient\u2019s history, clinical symptoms and laboratory findings, including SARS-CoV-2 testing (reference values given in brackets).<\/p>\n<\/div>\n

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<\/th>\nDay 1<\/th>\nDay 15<\/th>\nDay 18<\/th>\nDay 19<\/th>\nDay 20<\/th>\nDay 23<\/th>\nDay 24<\/th>\nDay 25<\/th>\nDay 26<\/th>\n<\/tr>\n<\/thead>\n
Major event<\/td>\nVaccination<\/td>\nCollapse during breakfast<\/td>\nAdmission to hospital; gastroscopy (mild gastritis)<\/td>\nAbdominal ultrasound, initiating intravenous iron application<\/td>\nColonoscopy (ischemic colitis), initiating mesalazine<\/td>\nAcute renal insufficiency, initiating intravenous glucose application<\/td>\nPatient in same hospital room has positive SARS-CoV-2 RT-PCR test (Ct, 15)<\/td>\nPatient somnolent, initiating antibiotic therapy, chest radiograph with minimal infiltrates<\/td>\nDeath at 14:30<\/td>\n<\/tr>\n
Leading clinical symptoms<\/td>\nNo relevant symptoms recorded<\/td>\nNo further relevant symptoms recorded<\/td>\nDiarrhea<\/td>\nAnemia<\/td>\nAnemia<\/td>\nLung auscultation with any pathological signs, hypernatremia<\/td>\nHypernatremia<\/td>\nDehydration, lung auscultation with crackles<\/td>\nAcute renal and respiratory failure<\/td>\n<\/tr>\n
Temperature (\u00b0C)<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\n36.4<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\n36.8<\/td>\n36.2<\/td>\n38.8<\/td>\nNot recorded<\/td>\n<\/tr>\n
Blood pressure (mmHg)<\/td>\nNot recorded<\/td>\n130\/70<\/td>\n187\/83<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\n180\/80<\/td>\n166\/73<\/td>\n160\/80<\/td>\nNot recorded<\/td>\n<\/tr>\n
Oxygen saturation (SpO2<\/sub>)<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\n97%<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\nNot recorded<\/td>\n97% + 2l O2<\/sub><\/td>\nNot recorded<\/td>\n<\/tr>\n
SARS-CoV-2 test<\/td>\nNo data<\/td>\nNo data<\/td>\nAntigen-test: negative
\nPCR-test: negative<\/td>\n		No data<\/td>\nPCR-test: negative<\/td>\nNo data<\/td>\nNo data<\/td>\nRT-PCR-test: positive (Ct, 20)<\/td>\nNo data<\/td>\n<\/tr>\n
White-cell count (4\u20139\/nl)<\/td>\nNo data<\/td>\nNo data<\/td>\n6.6<\/td>\n7.1<\/td>\n12.1<\/td>\n13.5<\/td>\nNo data<\/td>\n9.2<\/td>\n15.2<\/td>\n<\/tr>\n
Platelet count (140\u2013400\/nl)<\/td>\nNo data<\/td>\nNo data<\/td>\n267<\/td>\n263<\/td>\n262<\/td>\n254<\/td>\nNo data<\/td>\n204<\/td>\n196<\/td>\n<\/tr>\n
Hemoglobin (14.0\u201318.0 g\/dl)<\/td>\nNo data<\/td>\nNo data<\/td>\n7.4<\/td>\n7.1<\/td>\n7.2<\/td>\n8.0<\/td>\nNo data<\/td>\n8.6<\/td>\n9.3<\/td>\n<\/tr>\n
Lactate dehydrogenase (135\u2013250 U\/L)<\/td>\nNo data<\/td>\nNo data<\/td>\n179<\/td>\n165<\/td>\nNo data<\/td>\nNo data<\/td>\nNo data<\/td>\nNo data<\/td>\n439<\/td>\n<\/tr>\n
Creatinine (0.7\u20131.2 mg\/dl)<\/td>\nNo data<\/td>\nNo data<\/td>\n1.91<\/td>\n1.78<\/td>\nNo data<\/td>\n2.04<\/td>\nNo data<\/td>\n2.17<\/td>\n3.23<\/td>\n<\/tr>\n
C-reactive protein (<
\n0.5 mg\/dl)<\/td>\n		No data<\/td>\nNo data<\/td>\n1.0<\/td>\n0.8<\/td>\nNo data<\/td>\n2.0<\/td>\nNo data<\/td>\nNo data<\/td>\n8.8<\/td>\n<\/tr>\n
Sodium (135\u2013145 mmol\/l)<\/td>\nNo data<\/td>\nNo data<\/td>\n138<\/td>\n138<\/td>\nNo data<\/td>\n154<\/td>\n155<\/td>\nNo data<\/td>\n156<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n