Submitted by Harold Saive
Contents of “Comirnaty” are not the same as BNT162b2
“Summary Basis for Regulatory Action”, Page 14
“The repeat dose toxicity evaluations were conducted on COMIRNATY and a similar vaccine termed BNT162b2 (V8). COMIRNATY and BNT162b2 (V8) have identical amino acid sequences of the encoded antigens but COMIRNATY includes the presence of optimized codons to improve antigen expression.”
https://www.fda.gov/media/
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Codon Optimization
In 2011 Nature Medicine magazine published an article called “Breaking the Silence”. It described how codon optimization, which uses this synonymous DNA changes, can trigger disease in a number of ways.
Turns out the protein which was manufactured when codon optimization has different ways it folds and a different 3D shape, and it “could cause immunogenicity, for example, which wouldn’t be seen until late-stage clinical trials or even after approval”.
https://pingthread.com/thread/
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BREAKING THE SILENCE
Scientists had long assumed that any genetic mutation that does not alter a protein sequence should have no impact on human health. But recent research has shown that such synonymous DNA changes can trigger disease in a number of ways. Alla Katsnelson talks to scientists and biotech companies who are speaking up about ‘silent’ mutations.