Issue with the heavily codon-optimized mRNA vaccines! Vaccine spike protein might be different from SARS-CoV-2 spike!
Hello, I am Serdar Duzgoren from Romania.
The current Moderna vaccine might be creating a different shape protein! How;
I just found out that the same sequence of amino acids (same genetic sequence), but different codon usage can lead to different folding as a result of ‘codon bias’ which means a different shape protein as you have explained in your studies!
Prof.Baric and the VRC team have codon optimized the Sarscov2 sequence and sent it to Moderna on 14 Jan 2020. According to Prof.Xuhua Xia’s study, this sequence has many unnecessary codon changes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310186/
A deadly pathogen could have been engineered long ago with necessary epitope parts same as the spike protein of the Moderna vaccine encoded spike (which is different than Sarscov-2). In this way Only Moderna vaccinated people would survive when this deadly pathogen would be released in the future!
Why I started thinking of such a horrible scenario: Moderna vaccines have not been sold to over 165 countries. The coincidence is that these are mostly the African and S.American countries where the vaccination is slow and they are still vaccinating their priority risk groups people (old, sick, handicap….). Couple of months ago Moderna announced not selling their vaccines to any new countries until the second half of 2022. Which means Moderna vaccines will reach those countries at the time of vaccination of under 60 years of healthy people!
So, The shape of the vaccine spike can be different! What if it is what I am afraid of, which can only be achieved by immunising target people by a different shaped protein (to be the same as the protein of the real deadly pathogen) to give the intended immunity by using different (synonymous) codons?
Nobody ever checked the Moderna vaccine produced protein structure having new epitopes!
Can the structure of Moderna produced spike protein be compared with Sarscov-2’s spike?
Can it be checked If Moderna received people creating any new, unknown, different antibodies?
So is it possible that, even if Moderna is using the amino acid sequence of Sarscov-2, the vaccine spike protein can still have the shape of a spike of another pathogen due to many codon changes?
This is a major defect if the vaccine protein structure is different. It can cause the prion problem as well!
Kindly reply with your thoughts,
Best regards,
Serdar Duzgoren, +40732134134
https://osf.io/bcsa6/?fbclid=IwAR2ZlTRwhMCJd0ssfSIuugSgAfRK82VTRTzhp5N6zWOfwq6nnW420PAOX_E
https://blog.addgene.org/to-codon-optimize-or-not-that-is-the-question